Bcl-2-IN-5
Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155) [1].
Product Specifications
CAS Number
2728752-20-1
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-5.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1CN(CC2)C[C@](C3=C(C=CC=C3)C(C)C)([H])N2C(C4)CC4(C5)CN5C6=CC(OC7=CN=C(NC=C8F)C8=C7)=C(C(NS(=O)(C9=CC([N+]([O-])=O)=C(C=C9)NC[C@@H]%10CC[C@@](O)(CC%10)C)=O)=O)C=C6
Molecular Formula
C55H63FN8O8S
Molecular Weight
1015.20
References & Citations
[1]Hai Xue, et al. Bcl-2 inhibitor. WO2021208963A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2
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