Bcl-2-IN-4
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC50 of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC50 of 411 nM) . Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC50 of 2.7 nM (WO2021180040A1; compound 2) [1].
Product Specifications
CAS Number
2703134-40-9
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=C2C(N=CN2)=C(NCC3CCOCC3)C([N+]([O-])=O)=C1)=O)C4=CC=C(N5CCN(CC6=C(C7=CC=C(Cl)C=C7)CC(C)(C)CC6)CC5)C=C4OC8=CN=C(NC=C9)C9=C8
Molecular Formula
C46H50ClN9O7S
Molecular Weight
908.46
References & Citations
[1]Hongjian Wang, et al. Benzo five-membered cyclic compound. WO2021180040A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL
Frequently Asked Questions
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