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HPK1-IN-29

HPK1-IN-29 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-29 enhances the body's anti-tumor immunity. HPK1-IN-29 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 38) [1].

Product Specifications

CAS Number

2699604-50-5

UNSPSC

12352005

Target

MAP4K

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hpk1-in-29.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CN=C2NC=C(C2=C1OC3=C(C=C(NC4=NCC5(CC5)CO4)C=C3F)F)C6=CC=C(F)C=C6

Molecular Formula

C26H18F3N5O2

Molecular Weight

489.45

References & Citations

[1]Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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