HPK1-IN-28
HPK1-IN-28 is a potent inhibitor of HPK1. Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of the activation response of dendritic cells (DCs), T cells and B cells. HPK1-IN-28 enhances the body's anti-tumor immunity. HPK1-IN-28 has the potential for the research of immune-related diseases, especially tumor (extracted from patent WO2021175270A1, compound 1) [1].
Product Specifications
CAS Number
2699603-89-7
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hpk1-in-28.html
Solubility
10 mM in DMSO
Smiles
FC1=C(OC2=NC=NC3=C2C(C4=C(F)C=C(OC)C=C4)=CN3)C(F)=CC(NC5=NCC(CO)(CO5)C)=C1
Molecular Formula
C25H22F3N5O4
Molecular Weight
513.47
References & Citations
[1]Jiang Lei, et al. Novel hpk1 inhibitors and methods of preparation and application thereof. Patent WO2021175270A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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