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RIPK1-IN-9

RIPK1-IN-9 (example 45), a dihydronaphthyridone compound, is a potent and selective RIPK1 inhibitor. RIPK1-IN-9 inhibits U937 cell (IC50=2 nM) and L929 cell (IC50=1.3 nM) [1].

Product Specifications

CAS Number

2682889-57-0

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ripk1-in-9.html

Solubility

10 mM in DMSO

Smiles

O=C1C2=C(N=CC(C3=CC4=NC(N)=NN4C=C3)=C2)CCN1CC5=CC(F)=CC=C5OC6CCCC6

Molecular Formula

C26H25FN6O2

Molecular Weight

472.51

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Fusheng Zhou, et al. Dihydronaphthyridone compounds, their preparation and pharmaceutical uses. WO2021160109A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

Frequently Asked Questions

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