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JAK3/BTK-IN-4

JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-4 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 003) [1]

Product Specifications

CAS Number

[2673196-38-6]

UNSPSC

12352005

Target

Btk; JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/jak3-btk-in-4.html

Solubility

10 mM in DMSO

Smiles

C=CC(N(CCC1)CC21CCN2C3=C4C(NC=C4Cl)=NC(NC5=CN(CC)N=C5)=N3)=O

Molecular Formula

C21H25ClN8O

Molecular Weight

440.93

References & Citations

[1]Baoguo Zhang, et al. Pyrimidinopyrimidine and pentacyclic derivatives and their applications. Patent WO2021147953A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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