JAK3/BTK-IN-4
JAK3/BTK-IN-4 is a potent inhibitor of JAK3/BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signalling pathway exhibits synergistic effects. JAK3/BTK-IN-4 has the potential for the research of JAK3 kinase and/or BTK-related diseases (extracted from patent WO2021147953A1, compound 003) [1]
Product Specifications
CAS Number
[2673196-38-6]
UNSPSC
12352005
Target
Btk; JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak3-btk-in-4.html
Solubility
10 mM in DMSO
Smiles
C=CC(N(CCC1)CC21CCN2C3=C4C(NC=C4Cl)=NC(NC5=CN(CC)N=C5)=N3)=O
Molecular Formula
C21H25ClN8O
Molecular Weight
440.93
References & Citations
[1]Baoguo Zhang, et al. Pyrimidinopyrimidine and pentacyclic derivatives and their applications. Patent WO2021147953A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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