5-Aminosalicylic acid-13C6 (hydrochloride)

5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3].

Product Specifications

CAS Number

[1261398-47-3]

Product Name Alternative

Mesalamine-13C6 (hydrochloride) ; 5-ASA-13C6 (hydrochloride) ; Mesalazine-13C6 (hydrochloride)

UNSPSC

12352005

Target

NF-κB; PAK; PPAR

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-aminosalicylic-acid-13c6-hydrochloride.html

Purity

99.53

Solubility

10 mM in DMSO

Smiles

OC([13C]1=[13C]([13CH]=[13CH][13C](N)=[13CH]1)O)=O.Cl

Molecular Formula

C 13C6H8ClNO3

Molecular Weight

195.55

References & Citations

[1]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015;1853 (10 Pt A) :2349-2360.|[2]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013;34 (11) :2580-2586.|[3]Fang HM, et al. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007;13 (20) :2872-2877.