SQDG

SQDG inhibits topoisomerase I and P-selectin receptor, exhibits anti-inflammatory, antiviral and antitumor activities. SQDG is a glycolipid that possesses sugar moieties in their head groups. SQDG is a membrane lipid that can be used to investigate the effects of structural lipid in LNP formulations[1][2][3].

Product Specifications

CAS Number

[123036-44-2]

UNSPSC

12352200

Target

Apoptosis; HSV; Liposome; MDM-2/p53; Topoisomerase

Type

Biochemical Assay Reagents

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/sqdg.html

Purity

99.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming)

Smiles

CC/C=C\C/C=C\C/C=C\CCCCCCCC(OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)CO[C@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CS(=O)(O)=O)=O

Molecular Formula

C43H76O12S

Molecular Weight

817.12

References & Citations

[1]Jeonghwan Kim, et al. Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery. Cell Mol Bioeng. 2020 May 26;13 (5) :463-474.|[2]Nakajima Y, et al., Thylakoid membrane lipid sulfoquinovosyl-diacylglycerol (SQDG) is required for full functioning of photosystem II in Thermosynechococcus elongatus. J Biol Chem. 2018 Sep 21;293 (38) :14786-14797.|[3]Wang H, et al. Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa[J]. 2007.|[4]Jain CK, et al., Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo. Sci Rep. 2015 Jul 20;5:12082.