SH498

SH498, a novel Bmi-1-mediated antitumor agent, shows potent antiproliferative activity.

Product Specifications

CAS Number

[2125724-38-9]

UNSPSC

12352005

Target

Autophagy; BMI1

Type

Reference compound

Related Pathways

Autophagy; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sh498.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C=C1CCC2C3(C)C)=C(OC)C=C1[C@@]2(C)C=C(C#N)C3=O)NC4=CC=CC(OC(F)(F)F)=C4

Molecular Formula

C27H25F3N2O4

Molecular Weight

498.49

References & Citations

[1]Yang LF, et al. Synthesis of Cyanoenone-Modified Diterpenoid Analogs as Novel Bmi-1-Mediated Antitumor Agents. ACS Med Chem Lett. 2018 Sep 27;9 (11) :1105-1110.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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