SH379
SH379 is the derivative of 2-methylpyrimidine-fused tricyclic diterpene. SH379 is a potent and orally active anti-late-onset hypogonadism agent. SH379 significantly promotes the expression of the key testosterone synthesis-related enzymes StAR and 3β-HSD. SH379 stimulates autophagy through regulating AMPK/mTOR signaling pathway[1].
Product Specifications
CAS Number
2338793-00-1
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/sh379.html
Solubility
10 mM in DMSO
Smiles
C[C@@]12C3=CC(OC)=C(C(NC)=O)C=C3CC[C@@]1([H])C(C)(C4=NC(C)=NC=C4C2)C
Molecular Formula
C23H29N3O2
Molecular Weight
379.50
References & Citations
[1]Bai J, et al. Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents. Eur J Med Chem. 2019;176:21-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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