SH379

SH379 is the derivative of 2-methylpyrimidine-fused tricyclic diterpene. SH379 is a potent and orally active anti-late-onset hypogonadism agent. SH379 significantly promotes the expression of the key testosterone synthesis-related enzymes StAR and 3β-HSD. SH379 stimulates autophagy through regulating AMPK/mTOR signaling pathway[1].

Product Specifications

CAS Number

2338793-00-1

UNSPSC

12352005

Target

Autophagy

Type

Reference compound

Related Pathways

Autophagy

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/sh379.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12C3=CC(OC)=C(C(NC)=O)C=C3CC[C@@]1([H])C(C)(C4=NC(C)=NC=C4C2)C

Molecular Formula

C23H29N3O2

Molecular Weight

379.50

References & Citations

[1]Bai J, et al. Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents. Eur J Med Chem. 2019;176:21-40.