WW437

WW437 is a histone deacetylase (HDAC) inhibitor with potent anti-breast cancer ability in vitro and in vivo.

Product Specifications

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ww437.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1)N(C(CCCCCC(NO)=O)=O)CC2=CN(N=N2)C3=CC=CC=C3

Molecular Formula

C23H27N5O4

Molecular Weight

437.49

References & Citations

[1]Zhang T, et al. Inhibition of HDACs-EphA2 Signaling Axis with WW437 Demonstrates Promising Preclinical Antitumor Activity in Breast Cancer. EBioMedicine. 2018 May;31:276-286.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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