A-987306
A-987306 is a potent and oral bioavailable histamine H4 antagonist, with Kis of 3.4 nM and 5.8 nM for rat H4, and human H4. A-987306 shows anti-inflammatory activity in mice peritonitis model[1].
Product Specifications
CAS Number
1082954-71-9
UNSPSC
12352005
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a-987306.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(N2CCNCC2)=C3CCC(O[C@]4([H])[C@@]5([H])CCCC4)=C5C3=N1
Molecular Formula
C18H25N5O
Molecular Weight
327.42
References & Citations
[1]cis-4- (Piperazin-1-yl) -5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), A New Histamine H4R Antagonist that Blocks Pain Responses against Carrageenan-Induced Hyperalgesia
 J. Med. Chem., 2008, 51 (22), pp 7094-7098
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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