RET-IN-10
RET-IN-10 is a potent inhibitor of RET. RET loss of function mutations leads to Hirschsprung's disease, while its gain of function mutations is associated with a variety of human tumors. RET-IN-10 has the potential for the research of cancer diseases (extracted from patent WO2021135938A1, compound 18) [1].
Product Specifications
CAS Number
2662622-44-6
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-10.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2C(C3=CN=C(N4CCC(CC4)N=[S@](C5=CC=CC=C5)(C)=O)C=C3)=CC(C6=CN(C)N=C6)=CN2N=C1
Molecular Formula
C29H28N8OS
Molecular Weight
536.65
References & Citations
[1]Anhu Li. Heterocyclic sulfoximine compounds and intermediates thereof, methods of preparation and applications. Patent WO2021135938A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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