RET-IN-9
RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-pass transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, and the maintenance of homeostasis in the nervous, endocrine, hematopoietic, and male reproductive systems. RET-IN-9 has the potential for the research of RET-related disease including non-small cell lung cancer and medullary thyroid cancer (extracted from patent WO2021115457A1, compound 29) [1].
Product Specifications
CAS Number
2649418-11-9
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-9.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(NCC)=CN2N=C1
Molecular Formula
C26H27N9O
Molecular Weight
481.55
References & Citations
[1]Huimin Chen, et al. Pyrazolo[1,5-a]pyridine compounds and preparation method and application thereof. Patent WO2021115457A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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Protein S100-A9, Recombinant, Bovine, aa2-156, His-SUMO-tag, Myc-tag (S100A9)
Protein S100-A9, Recombinant, Bovine, aa2-156, His-SUMO-tag, Myc-tag (S100A9)
Protein S100-A9, Recombinant, Bovine, aa2-156, His-SUMO-tag, Myc-tag (S100A9)