ERCC1-XPF-IN-1
ERCC1-XPF-IN-1 is a potent and high-affinity ERCC1-XPF inhibitor with IC50 value of 0.49 μM. ERCC1-XPF-IN-1 has the capacity to potentiate the cytotoxicity effect of UV radiation and inhibiting DAN repair, by the inhibition of removal of CPDs, and cyclophosphamide toxicity to colorectal cancer cells[1].
Product Specifications
CAS Number
2411584-25-1
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ercc1-xpf-in-1.html
Purity
99.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(NC3=CC=C(O)C(CN4CCN(CCN(C)C)CC4)=C3)C5=CC=C(Cl)C=C5N=C2C=C1
Molecular Formula
C28H32ClN5O2
Molecular Weight
506.04
References & Citations
[1]Elmenoufy AH, Gentile F, Jay D, et al. Design, synthesis and in vitro cell-free/cell-based biological evaluations of novel ERCC1-XPF inhibitors targeting DNA repair pathway. Eur J Med Chem. 2020;204:112658.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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