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IRAK4-IN-10

IRAK4-IN-10 (compound 75) is a potent IRAK4 inhibitor with an IC50 of 1.5 nM. IRAK4-IN-10 blocks MyD88 dependent signaling. IRAK4-IN-9 has the potential for the research of inflammatory diseases, autoimmune diseases, and cancer[1].

Product Specifications

CAS Number

2681278-09-9

UNSPSC

12352005

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/irak4-in-10.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC2=C(C=C1)C3=NC=C(C4=CN(C5CCNCC5)N=N4)C(NC(C)C)=C3N2

Molecular Formula

C22H24N8

Molecular Weight

400.48

References & Citations

[1]Sabnis RW. Novel Tricyclic Heteroaryl Compounds as IRAK4 Inhibitors for Treating Cancer, Autoimmune and Inflammatory Diseases. ACS Med Chem Lett. 2022 Feb 28;13 (3) :336-337.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IRAK4

Frequently Asked Questions

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