Nav1.8-IN-2

Nav1.8-IN-2 (compound 35A) is a potent Nav1.8 inhibitor with an IC50 value of 0.4 nM. Nav1.8-IN-2 can be used for researching pain disorders, cough disorders, and acute and chronic itch disorders[1].

Product Specifications

CAS Number

[2756250-30-1]

UNSPSC

12352005

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nav1-8-in-2.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H]1OC(NC1)=O)N[C@@H](C2=CC=C(C=C2)Cl)C3=CC(C(F)(F)F)=C(C=C3)Cl

Molecular Formula

C18H13Cl2F3N2O3

Molecular Weight

433.21

References & Citations

[1]Sabnis RW. 2-Oxooxazolidine-5-carboxamides as Nav1.8 Inhibitors for Treating Pain Disorders, Cough Disorders, and Acute and Chronic Itch Disorders. ACS Med Chem Lett. 2022;13 (3) :334-335. Published 2022 Mar 1.