POP-IN-2
POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer[1].
Product Specifications
CAS Number
[2743432-81-5]
UNSPSC
12352005
Target
Prolyl Endopeptidase (PREP)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pop-in-2.html
Solubility
10 mM in DMSO
Smiles
CC(NC1=CC=C(C(N2C(B3O[C@@]4([H])[C@@]([C@](C5)([H])C(C)(C)[C@]5([H])C4)(C)O3)CCC2)=O)C(OC)=C1)=O
Molecular Formula
C24H33BN2O5
Molecular Weight
440.34
References & Citations
[1]Jessica Plescia, et al. Discovery of covalent prolyl oligopeptidase boronic ester inhibitors. Eur J Med Chem. 2020 Jan 1;185:111783.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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