CAXII-IN-1

CAXII-IN-1 (Compound 17) is a selective CA XII inhibitor with Ki values of 3.8 nM and 56.0 nM against hCA XII and hCA IX, respectively. CAXII-IN-1 shows antitumor activity[1].

Product Specifications

CAS Number

[2479918-59-5]

UNSPSC

12352005

Target

Carbonic Anhydrase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/caxii-in-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC(Cl)=CC(C2=CN=C(OS(C=C3)(=O)=O)C3=C2)=C1

Molecular Formula

C13H7Cl2NO3S

Molecular Weight

328.17

References & Citations

[1]Grandāne A, et al. Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII. Eur J Med Chem. 2020 Aug 15;200:112300.