Anti-inflammatory agent 19

Anti-inflammatory agent 19 (compound 2b) shows NO inhibitory activity, with an IC50 of 36.00 μM. Anti-inflammatory agent 19 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 19 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc[1].

Product Specifications

CAS Number

[2873386-63-9]

UNSPSC

12352211

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/anti-inflammatory-agent-19.html

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@@](C)([C@H]([C@H]4O)O)CO)C)C)([H])[C@](C)([C@](CC1)([H])[C@](C)(O)CO)CCC(O)=O

Molecular Formula

C30H50O7

Molecular Weight

522.71

References & Citations

[1]Zhu Y, et al. Microbial transformation of pentacyclic triterpenes for anti-inflammatory agents on the HMGB1 stimulated RAW 264.7 cells by Streptomyces olivaceus CICC 23628. Bioorg Med Chem. 2021 Dec 15;52:116494.