MtTMPK-IN-4
Product Specifications
UNSPSC Description
MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent[1][2].
Target Antigen
Bacterial; Tyrosinase
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mttmpk-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC=CC=C4)=CC=C3
Molecular Weight
391.46
References & Citations
[1]Lijun Song, et al. Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J Med Chem. 2018 Apr 12;61(7):2753-2775. |[2]Jin Li, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021 Nov 15;224:113744.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143452/MtTMPK-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143452/
Clinical Information
No Development Reported
CAS Number
2225889-49-4
Curated Selection
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