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MtTMPK-IN-4

MtTMPK-IN-4 (compound 2), a para-piperidine, is a potent mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 of 6.1 μM. MtTMPK-IN-4 is a potent tyrosinase inhibitor. MtTMPK-IN-4 is a potent antibacterial agent[1][2].

Product Specifications

CAS Number

[2225889-49-4]

UNSPSC

12352005

Target

Bacterial; Tyrosinase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mttmpk-in-4.html

Solubility

10 mM in DMSO

Smiles

CC1=CN(C(NC1=O)=O)C2CCN(CC2)CC3=CC(OC4=CC=CC=C4)=CC=C3

Molecular Formula

C23H25N3O3

Molecular Weight

391.46

References & Citations

[1]Lijun Song, et al. Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. J Med Chem. 2018 Apr 12;61 (7) :2753-2775. |[2]Jin Li, et al. Recent advances in the design and discovery of synthetic tyrosinase inhibitors. Eur J Med Chem. 2021 Nov 15;224:113744.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-143452/MtTMPK-IN-4-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-143452/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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