CBP/p300-IN-18
CBP/p300-IN-18 (compound 8) is a potent EP300/CBP HAT inhibitor with IC50s of 0.056, 0.46 µM for HAT EP300 and LK2 H3K27, respectively[1].
Product Specifications
CAS Number
[2983027-64-9]
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)C[C@H](F)C1)NC4=CC=CC5=C4C=NN5
Molecular Formula
C25H27FN4O3
Molecular Weight
450.51
References & Citations
[1]Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
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