CBP/p300-IN-16

CBP/p300-IN-16 (compound 1) is a potent EP300/CBP HAT inhibitor with IC50s of 0.61, 2.24 µM for HAT EP300 and LK2 H3K27, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cbp-p300-in-16.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCOC[C@H](CC2=CC=CC3=C2C=NN3)C1)C4(C5=CC=C(OC)C=C5)CCOCC4

Molecular Formula

C26H31N3O4

Molecular Weight

449.54

References & Citations

[1]Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CBP/p300; TIP60

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