CBP/p300-IN-16
CBP/p300-IN-16 (compound 1) is a potent EP300/CBP HAT inhibitor with IC50s of 0.61, 2.24 µM for HAT EP300 and LK2 H3K27, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-in-16.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCOC[C@H](CC2=CC=CC3=C2C=NN3)C1)C4(C5=CC=C(OC)C=C5)CCOCC4
Molecular Formula
C26H31N3O4
Molecular Weight
449.54
References & Citations
[1]Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300; TIP60
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