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TNIK-IN-4

TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1].

Product Specifications

CAS Number

2754266-04-9

UNSPSC

12352005

Target

Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tnik-in-4.html

Solubility

10 mM in DMSO

Smiles

O=C1OC2=CC(C3=CC(OC)=C(N)N=C3)=CC=C2N1CC4=CC=C(F)C=C4

Molecular Formula

C20H16FN3O3

Molecular Weight

365.36

References & Citations

[1]Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2 (3H) -one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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