(R) -MALT1-IN-3
(R) -MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R) -MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively[1].
Product Specifications
CAS Number
[2504229-61-0]
UNSPSC
12352005
Target
MALT1
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-malt1-in-3.html
Solubility
10 mM in DMSO
Smiles
CO[C@H](C1CC1)C2=C(C#N)C(C)=NC=C2NC(NC3=CN=C(N4N=CC=N4)C(C(F)(F)F)=C3)=O
Molecular Formula
C21H19F3N8O2
Molecular Weight
472.42
References & Citations
[1]Johannes Wilhelmus J Thuring, et al. Pyridine rings containing derivatives as malt1 inhibitors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
130554-AP 100 µL
NR3C1 (Glucocorticoid Receptor, GR, Nuclear Receptor Subfamily 3 Group C Member 1, GRL) (AP) discontinued
Ask
View Details