ATX inhibitor 14
ATX inhibitor 14 (compound 4), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 0.41 nM. ATX inhibitor 14 has the potential for fibrosis relevant diseases research[1].
Product Specifications
CAS Number
2484811-39-2
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atx-inhibitor-14.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CN(CC)C2=C1C=C(C3=NC(CN4CCOCC4)=CS3)C=C2)OCC5=CC(Cl)=CC(Cl)=C5
Molecular Formula
C26H26Cl2N4O3S
Molecular Weight
545.48
References & Citations
[1]Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
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