Antimalarial agent 10

Antimalarial agent 10 (Compound 17b) is an aminoalcohol quinoline compound. Antimalarial agent 10 is an antimalarial agent with IC50 values of 14.9 nM and 11.0 nM against respectively Pf3D7 and PfW2 and a selectivity index higher than 770 whatever the cell line is[1].

Product Specifications

CAS Number

[2747280-03-9]

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/antimalarial-agent-10.html

Solubility

10 mM in DMSO

Smiles

FC(F)(C1=CC=CC2=C1N=C(C(F)(F)F)C=C2[C@H](O)CN[C@H](COC)CC3=CC=CC=C3)F

Molecular Formula

C23H22F6N2O2

Molecular Weight

472.42

References & Citations

[1]Dassonville-Klimpt A, et al. Design, synthesis, and characterization of novel aminoalcohol quinolines with strong in vitro antimalarial activity. Eur J Med Chem. 2022;228:113981.