OYYF-175
OYYF-175, an antimicrobial antifolate, is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 2.36 nM for Escherichia coli DHFR. OYYF-175 exhibits potent broad-spectrum antibacterial activities, especially against multi-drug resistant Gram-Negative-strains[1].
Product Specifications
CAS Number
65829-22-3
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/oyyf-175.html
Solubility
10 mM in DMSO
Smiles
NC1=C2C3=C(N(CC4=CC=CC=C4F)C=C3)C=CC2=NC(N)=N1
Molecular Formula
C17H14FN5
Molecular Weight
307.32
References & Citations
[1]Yue Li, et al. The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur J Med Chem. 2022 Jan 15;228:113979.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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