Hit 1
Hit 1 is an activator of ansulin degrading enzyme (IDE), with an EC50 of 5.5 μM. Hit 1 can decrease glucose-stimulating insulin secretion[1].
Product Specifications
CAS Number
2785377-42-4
UNSPSC
12352005
Target
Proteolytic Enzyme
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hit-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCN1C=CN=C1)CCCC2=CN(C3=CC=CC=C23)S(=O)(C4=CC=CS4)=O
Molecular Formula
C22H24N4O3S2
Molecular Weight
456.58
References & Citations
[1]Kraupner N, et, al. Identification of indole-based activators of insulin degrading enzyme. Eur J Med Chem. 2022 Jan 15;228:113982.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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