TRIM24/BRPF1-IN-2
TRIM24/BRPF1-IN-2 (compound 20l) is a potent TRIM24/BRPF1 dual inhibitor, with IC50 values of 0.98 and 1.16 μM, respectively. TRIM24/BRPF1-IN-2 shows TRIM24/BRPF1 bromodomain binding affinity. TRIM24/BRPF1-IN-2 can be used for prostate cancer research[1].
Product Specifications
CAS Number
[3033288-68-2]
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/trim24-brpf1-in-2.html
Purity
98.74
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1S(=O)(NC2=CC=C3C(CCN3C(C)=O)=C2)=O)C4CC4
Molecular Formula
C20H22N2O4S
Molecular Weight
386.46
References & Citations
[1]Xiang Q, et al. Discovery, optimization and evaluation of 1- (indolin-1-yl) ethan-1-ones as novel selective TRIM24/BRPF1 bromodomain inhibitors. Eur J Med Chem. 2022 Jun 5;236:114311.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRPF1
Available Sizes
Curated Selection
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