XY153

XY153 (compound 8l) is a BD2-selective BET inhibitor and selectively binds to BRD4 BD2. XY153 binds to BRD4 BD2, BRD3 BD2 and BRD2 BD2 with IC50s of 0.79, 5.31 and 5.09 nM, respectively. XY153 shows potent antiproliferative activity against multiple tumor cell lines. XY153 can be used for the research of acute myeloid leukemia (AML) and cancer[1].

Product Specifications

CAS Number

[2933176-32-8]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/xy153.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(F)=CC(C)=C1OC2=C(C=C(C=C2)C(C)(O)C)C3=CN(C(C4=C3OC(C5=CN=C(N5)C6CCCC6)=C4)=O)C

Molecular Formula

C33H34FN3O4

Molecular Weight

555.64

References & Citations

[1]Li J, et al. Structure-Based Discovery and Optimization of Furo[3,2-c]pyridin-4 (5H) -one Derivatives as Potent and Second Bromodomain (BD2) -Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J Med Chem. 2022 Apr 14;65 (7) :5760-5799.