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(R) -V-0219

(R) -V-0219 is an enantiomer of V-0219. V-0219 is an orally active and positive allosteric modulator (PAM) of the GLP Receptor-1 (GLP-1R). (R) -V-0219 activates calcium fluxes in HEK cells stably expressing hGLP-1R[1].

Product Specifications

CAS Number

3031984-80-9

UNSPSC

12352005

Target

GLP Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/r-v-0219.html

Solubility

10 mM in DMSO

Smiles

FC(C1=CC=C(C2=NOC(CN3C[C@@H](CN4CCOCC4)CCC3)=N2)C=C1)(F)F

Molecular Formula

C20H25F3N4O2

Molecular Weight

410.43

References & Citations

[1]Decara JM, et al. Discovery of V-0219: A Small-Molecule Positive Allosteric Modulator of the Glucagon-Like Peptide-1 Receptor toward Oral Treatment for "Diabesity". J Med Chem. 2022 Apr 14;65 (7) :5449-5461.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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