Topoisomerase I inhibitor 4
Product Specifications
UNSPSC Description
Topoisomerase I inhibitor 4 (compound 7a) is a topoisomerase I inhibitor. Topoisomerase I inhibitor 4 inhibits HepG2, A549, MCF-7 and HeLa cancer cells proliferation with IC50s of 1.20, 2.09, 1.56 and 1.92 μM, respectively. Topoisomerase I inhibitor 4 can be used for the research of cancer[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N=C3C4=CC5=CC=CC=C5C=C4CN13)C=C(C(F)=C2)N6CCNCC6
Molecular Weight
386.42
References & Citations
[1]Xiang, Y, et al. Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors. Med Chem Res 30, 1512–1522 (2021).
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143301/Topoisomerase-I-inhibitor-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143301/
Clinical Information
No Development Reported
CAS Number
2485135-31-5
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