ABT-724
ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM) . ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].
Product Specifications
CAS Number
70006-24-5
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/abt-724.html
Solubility
10 mM in DMSO
Smiles
C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1
Molecular Formula
C17H19N5
Molecular Weight
293.37
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
D4 Receptor; D5 Receptor
Available Sizes
Frequently Asked Questions
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