ABT-724

ABT-724, a chemical probe, is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM) . ABT-724 has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 could be useful for the treatment of erectile dysfunction and has favorable side-effect profile[1].

Product Specifications

CAS Number

[70006-24-5]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/abt-724.html

Solubility

10 mM in DMSO

Smiles

C1(NC(CN2CCN(C3=NC=CC=C3)CC2)=N4)=C4C=CC=C1

Molecular Formula

C17H19N5

Molecular Weight

293.37

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1] Brioni JD, et al. Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats. Proc Natl Acad Sci U S A. 2004 Apr 27;101 (17) :6758-63.