NTPDase-IN-1

NTPDase-IN-1 (compound 5a) is a selective NTPDase inhibitor with IC50s of 0.05, 0.23 and 0.54 µM for h-NTPDase-1/-2/-8, respectively. NTPDase-IN-1 non-competitively inhibits h-NTPDase-1/-2 with a Km of 21 µM for h-NTPDase-1. NTPDase-IN-1 can be used in studies of cancer, immunologic disorders as well as bacterial infections[1].

Product Specifications

CAS Number

[2962812-29-7]

UNSPSC

12352005

Target

NTPDase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ntpdase-in-1.html

Solubility

10 mM in DMSO

Smiles

CCCSC1=NN=C(S1)NC(C(C2=CC=C(C=C2)CC(C)C)C)=O

Molecular Formula

C18H25N3OS2

Molecular Weight

363.54

References & Citations

[1]Abbas S, et al. Synthesis, characterization and biological evaluation of thiadiazole amide derivatives as nucleoside triphosphate diphosphohydrolases (NTPDases) inhibitors. Bioorg Chem. 2022 Jan;118:105456.