PF15
PF15 is a PROTAC connected by ligands for FLT3 kinase and CRBN. PF15 is a high selective FLT3-ITD degrader, with a DC50 of 76.7 nM. PF15 significantly inhibits the proliferation of FLT3-ITD-positive cells, can down-regulate the phosphorylation of FLT3 and STAT5. PF15 also inhibits tumor growth in mouse models and can be used in study of leukemia[1].
Product Specifications
CAS Number
[2892631-70-6]
UNSPSC
12352005
Target
FLT3; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pf15.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C1=CC(NC(NC2=CC=C(C=C2)C3=CN(C4=NC=NC(N)=C34)CCCCC5=CN(N=N5)CCCCC(NC6=C7CN(C(C7=CC=C6)=O)C8CCC(NC8=O)=O)=O)=O)=NO1)C
Molecular Formula
C44H49N13O6
Molecular Weight
855.94
References & Citations
[1]Chen Y, et al. Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC) . Bioorg Chem. 2022 Feb;119:105508.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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