Topoisomerase II inhibitor 4
Selected Variant
HY-143280
Size: 1 Each
Topoisomerase II inhibitor 4 (compound E17) is a potent Topoisomerase II inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect[1].
Product Specifications
CAS Number
2560590-49-8
UNSPSC
12352005
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C([N+]([O-])=O)=CC=C2NC3=CC=C(CN4CCN(C)CC4)C=C3)NC5=C1C=C(O)C=C5
Molecular Formula
C25H25N5O4
Molecular Weight
459.50
References & Citations
[1]Li ZY, et al. Structural optimizations and bioevaluation of N-substituted acridone derivatives as strong topoisomerase II inhibitors. Bioorg Chem. 2022 Feb. 119:105543.|[2]Chen JN, et al. E17 exerts anti-tumor activity through inhibiting topo II-mediated chromosomes condensation in CRC cells. Biochem Biophys Res Commun. 2019 May 28. 513 (2) :313-318.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Price
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