FLT3-IN-13
FLT3-IN-13 (compound 20) is a potent and effective antileukemic topoisomerase II and FLT3 dual inhibitor with IC50 values of 2.26 μM and 2.26 μM, respectively. FLT3-IN-13 arrests cell cycle at G2/M phase and induce apoptosis. FLT3-IN-13 has anticytotoxic activity, particularly against leukemia[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; FLT3; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-in-13.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C(C(N/N=C/C3=CC=NC=C3)=O)=CC=C2)NC4=C1C=CC=C4
Molecular Formula
C20H14N4O2
Molecular Weight
342.35
References & Citations
[1]Abdelgawad MA, et al. Design, synthesis, and biological evaluation of novel pyrido-dipyrimidines as dual topoisomerase II/FLT3 inhibitors in leukemia cells. Bioorg Chem. 2022 May;122:105752.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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