DENV-IN-5
DENV-IN-5 (Compound 4b) is a dengue virus (DENV) inhibitor with EC50s of 1.47, 9.23, 7.08 and 8.91 μM against DENV-I ∼ IV replication, respectively. DENV-IN-5 also inhibits HIV-1IIIB strain with an EC50 of 0.1512 μM[1].
Product Specifications
CAS Number
[2375781-06-7]
UNSPSC
12352005
Target
Dengue Virus; DNA/RNA Synthesis; Flavivirus; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/denv-in-5.html
Solubility
10 mM in DMSO
Smiles
CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC(F)=C(C=C3)F)=C2Cl)CC4CCCCC4
Molecular Formula
C23H25ClF2N4OS
Molecular Weight
478.99
References & Citations
[1]Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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