DENV-IN-6
DENV-IN-6 is a potent DENV (I-IV) inhibitor with EC50s of 17.5, 13.20, 6.8 and 11.41 μM for the inhibition of DENV (I-IV) replication, respectively. DENV-IN-6 also exhibits activity of anti-HIV-1IIIB (EC50=0.0181 μM; CC50=64.92 μM) [1].
Product Specifications
CAS Number
2375780-95-1
UNSPSC
12352005
Target
DNA/RNA Synthesis; HIV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/denv-in-6.html
Solubility
10 mM in DMSO
Smiles
CCC1=C(N=C(NC1=O)SCC2=NNC(C3=CC=C(C=C3)F)=C2Cl)CC4CCCCC4
Molecular Formula
C23H26ClFN4OS
Molecular Weight
461.00
References & Citations
[1]Rui RM, et al. C6-structural optimizations of 2-aryl-1H-pyrazole-S-DABOs: From anti-HIV to anti-DENV activity. Bioorg Chem. 2022 Feb;119:105494.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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