PROTAC BRD9-binding moiety 5
PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].
Product Specifications
CAS Number
893633-37-9
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd9-binding-moiety-5.html
Solubility
10 mM in DMSO
Smiles
CCC1=NN=C2C(NC3=CC(NC(C)=O)=CC=C3)=NC4=C(N12)C=CC=C4
Molecular Formula
C19H18N6O
Molecular Weight
346.39
References & Citations
[1]Pierri M, et al. Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders. Bioorg Chem. 2022 Jan;118:105480.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD9
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