PROTAC BRD9-binding moiety 5

PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells[1].

Product Specifications

CAS Number

[893633-37-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-brd9-binding-moiety-5.html

Solubility

10 mM in DMSO

Smiles

CCC1=NN=C2C(NC3=CC(NC(C)=O)=CC=C3)=NC4=C(N12)C=CC=C4

Molecular Formula

C19H18N6O

Molecular Weight

346.39

References & Citations

[1]Pierri M, et al. Introducing structure-based three-dimensional pharmacophore models for accelerating the discovery of selective BRD9 binders. Bioorg Chem. 2022 Jan;118:105480.