HPA-IN-2

HPA-IN-2 (Compound 2a-1) is a potent and selective human pancreatic α-amylase (HPA) inhibitor with IC50 values of 8.2 μM and 450.7 μM against HPA and α-glucosidase, respectively[1].

Product Specifications

CAS Number

[2885971-91-3]

UNSPSC

12352005

Target

Amylases; Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hpa-in-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CN(N=N1)CCCCCCO[C@@H]2CC3=CC(O)=CC(O)=C3O[C@@H]2C4=CC(O)=C(C(O)=C4)O)/C=C/C5=CC=C(C(O)=C5)O

Molecular Formula

C33H36N4O10

Molecular Weight

648.66

References & Citations

[1]Chen W, et al. Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives. Bioorg Chem. 2022 Feb;119:105515.