HPA-IN-1
HPA-IN-1 (Compound 1) is a potent and selective human pancreatic α-amylase (HPA) inhibitor with IC50 values of 12.0 μM and 410.4 μM against HPA and α-glucosidase, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Amylases; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/hpa-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCC1=CN(N=N1)CCCCCCOC2=C(OC3=C(C=C(C=C3C2=O)O)O)C4=CC(O)=C(C(O)=C4)O)/C=C/C5=CC=C(C(O)=C5)O
Molecular Formula
C33H32N4O11
Molecular Weight
660.63
References & Citations
[1]Chen W, et al. Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives. Bioorg Chem. 2022 Feb;119:105515.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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