Topoisomerase I inhibitor 3
Selected Variant
HY-143266
Size: 1 Each
Topoisomerase I inhibitor 3 (Compound ZML-14) is a topoisomerase I inhibitor and can interact with topoisomerase I-DNA complex. Topoisomerase I inhibitor 3 induces HepG2 cell apoptosis and arrests cell cycle at G2/M phase[1].
Product Specifications
CAS Number
2588211-50-9
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-3.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2N=C3COC4=C(C3=CC2=C1)C=C(F)C=C4)OC
Molecular Formula
C18H14FNO3
Molecular Weight
311.31
References & Citations
[1]Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May;122:105747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
Price
Frequently Asked Questions
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