Topoisomerase I inhibitor 2
Topoisomerase I inhibitor 2 (ZML-8) is a highly selective inhibitor of DNA topoisomerase I (Top1) . Topoisomerase I inhibitor 2 inhibits Top1 activity and results DNA damage. Topoisomerase I inhibitor 2 blocks G2/M phase and induces apoptosis, exhibits anti-tumor effect[1].
Product Specifications
CAS Number
2588211-44-1
UNSPSC
12352005
Target
Apoptosis; Caspase; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-i-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2N=C3COC4=C(C3=CC2=C1)C=CC=C4)OC
Molecular Formula
C18H15NO3
Molecular Weight
293.32
References & Citations
[1]Zhou Y, et al. Design and synthesis of Aza-boeravinone derivatives as potential novel topoisomerase I inhibitors. Bioorg Chem. 2022 May. 122:105747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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